HIF-1 and hypoxic response: the plot thickens

被引：132

作者：

Poellinger, L ^{[1
]}

Johnson, RS

机构：

[1] Karolinska Inst, Stockholm, Sweden

[2] Univ Calif San Diego, Div Biol Sci, Mol Biol Sect, San Diego, CA 92103 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2004年 / 14卷 / 01期

关键词：

D O I：

10.1016/j.gde.2003.12.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hypoxia, or lowered physiological oxygenation, is a component of many diseases. The response to decreased oxygen tensions is also an essential aspect of normal development and physiology. The hypoxic response is chiefly mediated by a single transcription factor - the hypoxia-inducible transcription factor HIF-1. The central role played by HIF-1 in hypoxia-induced transcription has made the focus of intense investigation by biologists from a wide range of disciplines. Recent developments have produced fundamental advances in our understanding of both the regulation and function of this response pathway in animals, and illustrated the potential for manipulation of the pathway for therapeutic purposes.

引用

页码：81 / 85

页数：5

共 45 条

[1] Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia [J].

Ang, SO ;

Chen, H ;

Hirota, K ;

Gordeuk, VR ;

Jelinek, J ;

Guan, YL ;

Liu, EL ;

Sergueeva, AI ;

Miasnikova, GY ;

Mole, D ;

Maxwell, PH ;

Stockton, DW ;

Semenza, GL ;

Prchal, JT .

NATURE GENETICS, 2002, 32 (04) :614-621

[2] HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia [J].

Berra, E ;

Benizri, E ;

Ginouvès, A ;

Volmat, V ;

Roux, D ;

Pouysségur, J .

EMBO JOURNAL, 2003, 22 (16) :4082-4090

[3] The hypoxic response of tumors is dependent on their microenvironment [J].

Blouw, B ;

Song, HQ ;

Tihan, T ;

Bosze, J ;

Ferrara, N ;

Gerber, HP ;

Johnson, RS ;

Bergers, G .

CANCER CELL, 2003, 4 (02) :133-146

[4] A conserved family of prolyl-4-hydroxylases that modify HIF [J].

Bruick, RK ;

McKnight, SL .

SCIENCE, 2001, 294 (5545) :1337-1340

[5] Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia [J].

Brusselmans, K ;

Compernolle, V ;

Tjwa, M ;

Wiesener, MS ;

Maxwell, PH ;

Collen, D ;

Carmeliet, P .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (10) :1519-1527

[6] Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein [J].

Cockman, ME ;

Masson, N ;

Mole, DR ;

Jaakkola, P ;

Chang, GW ;

Clifford, SC ;

Maher, ER ;

Pugh, CW ;

Ratcliffe, PJ ;

Maxwell, PH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (33) :25733-25741

[7] Loss of HIF-2 and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice [J].

Compernolle, V ;

Brusselmans, K ;

Acker, T ;

Hoet, P ;

Tjwa, M ;

Beck, H ;

Plaisance, S ;

Dor, Y ;

Keshet, E ;

Lupu, F ;

Nemery, B ;

Dewerchin, M ;

Van Veldhoven, P ;

Plate, K ;

Moons, L ;

Collen, D ;

Carmeliet, P .

NATURE MEDICINE, 2002, 8 (07) :702-710

[8] HIF-1α is essential for myeloid cell-mediated inflammation [J].

Cramer, T ;

Yamanishi, Y ;

Clausen, BE ;

Förster, I ;

Pawlinski, R ;

Mackman, N ;

Haase, VH ;

Jaenisch, R ;

Corr, M ;

Nizet, V ;

Firestein, GS ;

Gerber, HP ;

Ferrara, N ;

Johnson, RS .

CELL, 2003, 112 (05) :645-657

[9] C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation [J].

Epstein, ACR ;

Gleadle, JM ;

McNeill, LA ;

Hewitson, KS ;

O'Rourke, J ;

Mole, DR ;

Mukherji, M ;

Metzen, E ;

Wilson, MI ;

Dhanda, A ;

Tian, YM ;

Masson, N ;

Hamilton, DL ;

Jaakkola, P ;

Barstead, R ;

Hodgkin, J ;

Maxwell, PH ;

Pugh, CW ;

Schofield, CJ ;

Ratcliffe, PJ .

CELL, 2001, 107 (01) :43-54

[10] HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration [J].

Grimm, C ;

Wenzel, A ;

Groszer, M ;

Mayser, H ;

Seeliger, M ;

Samardzija, M ;

Bauer, C ;

Gassmann, M ;

Remé, CE .

NATURE MEDICINE, 2002, 8 (07) :718-724

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