Safeguarding patients in clinical trials with high mortality rates

被引：51

作者：

Freeman, BD

Danner, RL

Banks, SM

Natanson, C

机构：

[1] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA

[2] NIH, Dept Crit Care Med, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2001年 / 164卷 / 02期

关键词：

D O I：

10.1164/ajrccm.164.2.2011028

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

引用

页码：190 / 192

页数：3

共 21 条

[1]

BENGISSON BA, 1999, LANCET, V354, P2222

[2] DIFFERENTIAL HEMODYNAMIC-EFFECTS OF L-NMMA IN ENDOTOXEMIC AND NORMAL DOGS [J].

COBB, JP ;

NATANSON, C ;

QUEZADO, ZMN ;

HOFFMAN, WD ;

KOEV, CA ;

BANKS, S ;

CORREA, R ;

LEVI, R ;

ELIN, RJ ;

HOSSEINI, JM ;

DANNER, RL .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1995, 268 (04) :H1634-H1642

[3] The agonising negative trend in monitoring of clinical trials [J].

DeMets, DL ;

Pocock, SJ ;

Julian, DG .

LANCET, 1999, 354 (9194) :1983-1988

[4] Growth hormone therapy in critically ill patients [J].

Demling, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (11) :837-839

[5] Multi-center, randomized, placebo-controlled, double blind study of the nitric oxide synthase inhibitor 546C88: Effect on survival in patients with septic shock [J].

Grover, R ;

Lopez, A ;

Lorente, J ;

Steingrub, J ;

Bakker, J ;

Willatts, S ;

McLuckie, A ;

Takala, J .

CRITICAL CARE MEDICINE, 1999, 27 (01) :A33-A33

[6] An open-label dose escalation study of the nitric oxide synthase inhibitor, NG-methyI-L-arginine hydrochloride (546C88), in patients with septic shock [J].

Grover, R ;

Zaccardelli, D ;

Colice, G ;

Guntupalli, K ;

Watson, D ;

Vincent, JL .

CRITICAL CARE MEDICINE, 1999, 27 (05) :913-922

[7]

GROVER R, 1998, CRIT CARE MED S, V26, pA29

[8] Dose-dependent effect of diaspirin cross-linked hemoglobin on regional blood circulation of severely hemorrhaged rats [J].

Gulati, A ;

Sen, AP .

SHOCK, 1998, 9 (01) :65-73

[9] Pharmacokinetics of the nitric oxide synthase inhibitor L-NG-methylarginine hydrochloride in patients with septic shock [J].

Hussein, Z ;

Beerahee, M ;

Grover, R ;

Jordan, B ;

Jeffs, R ;

Donaldson, J ;

Zaccardelli, D ;

Colice, G ;

Guntupalli, K ;

Watson, D ;

Vincent, JL .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1999, 65 (01) :1-9

[10]

KNOX J, 1995, J TRAUMA, V39, P526

← 1 2 3 →