Betaine and nonalcoholic steatohepatitis: Back to the future?

被引：23

作者：

Mukherjee, Sandeep ^{[1
]}

机构：

[1] Nebraska Med Ctr, Sect Gastroenterol & Hepatol, Omaha, NE 68198 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2011年 / 17卷 / 32期

关键词：

Betaine; Nonalcoholic steatohepatitis; Cirrhosis; Obesity; Insulin resistance; FATTY LIVER;

D O I：

10.3748/wjg.v17.i32.3663

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Nonalcoholic steatohepatitis (NASH) is an important indication for liver transplantation in many Western countries. Obesity and insulin resistance are the two most common risk factors for NASH, which can lead to recurrent NASH after liver transplantation. There is currently no approved therapy for NASH, and treatment is directed at risk factor modification and lifestyle changes. Betaine has been used for NASH, with mixed results, and may show promise in conjunction with other agents in clinical trials. (C) 2011 Baishideng. All rights reserved.

引用

页码：3663 / 3664

页数：2

共 11 条

[1]

Betaine for Nonalcoholic Fatty Liver Disease: Results of a Randomized Placebo-Controlled Trial [J].

Abdelmalek, Manal F. ;

Sanderson, Schuyler O. ;

Angulo, Paul ;

Soldevila-Pico, Consuelo ;

Liu, Chen ;

Peter, Joy ;

Keach, Jill ;

Cave, Matt ;

Chen, Theresa ;

McClain, Craig J. ;

Lindor, Keith D. .

HEPATOLOGY, 2009, 50 (06) :1818-1826

[2]

Abdelmalek MF, 2001, AM J GASTROENTEROL, V96, P2711

[3]

SERUM BETAINE, N,N-DIMETHYLGLYCINE AND N-METHYLGLYCINE LEVELS IN PATIENTS WITH COBALAMIN AND FOLATE-DEFICIENCY AND RELATED INBORN-ERRORS OF METABOLISM [J].

ALLEN, RH ;

STABLER, SP ;

LINDENBAUM, J .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1993, 42 (11) :1448-1460

[4]

Brunt EM, 1999, AM J GASTROENTEROL, V94, P2467, DOI 10.1111/j.1572-0241.1999.01377.x

[5]

The Natural History of Non-Alcoholic Fatty Liver Disease [J].

Caldwell, Stephen ;

Argo, Curtis .

DIGESTIVE DISEASES, 2010, 28 (01) :162-168

[6]

Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease [J].

Charlton, M ;

Kasparova, P ;

Weston, S ;

Lindor, K ;

Maor-Kendler, Y ;

Wiesner, RH ;

Rosen, CB ;

Batts, KP .

LIVER TRANSPLANTATION, 2001, 7 (07) :608-614

[7]

Craig SAS, 2004, AM J CLIN NUTR, V80, P539

[8]

Nonobese Population in a Developing Country Has a High Prevalence of Nonalcoholic Fatty Liver and Significant Liver Disease [J].

Das, Kausik ;

Das, Kshaunish ;

Mukherjee, Partha S. ;

Ghosh, Ali ;

Ghosh, Sumantra ;

Mridha, Asit R. ;

Dhibar, Tapan ;

Bhattacharya, Bhaskar ;

Bhattacharya, Dilip ;

Manna, Byomkesh ;

Dhali, Gopal K. ;

Santra, Amal ;

Chowdhury, Abhijit .

HEPATOLOGY, 2010, 51 (05) :1593-1602

[9]

Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine [J].

Kathirvel, Elango ;

Morgan, Kengathevy ;

Nandgiri, Ganesh ;

Sandoval, Brian C. ;

Caudill, Marie A. ;

Bottiglieri, Teodoro ;

French, Samuel W. ;

Morgan, Timothy R. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2010, 299 (05) :G1068-G1077

[10]

Miglio F, 2000, ARZNEIMITTEL-FORSCH, V50, P722

← 1 2 →