Studies in marine macrolide synthesis: Stereocontrolled synthesis of the AB-spiroacetal subunit of spongistatin 1 (altohyrtin A).

被引：106

作者：

Paterson, I

Oballa, RM

Norcross, RD

机构：

[1] University Chemical Laboratory, Cambridge CB2 1EW, Lensfield Road

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 47期

关键词：

D O I：

10.1016/0040-4039(96)01961-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The C-1-C-13 subunit 2, containing the AB-spiroacetal ring system of spongistatin 1 (1), was prepared in 11 steps with 90% ds from 3-benzyloxypropanal. Key steps include (i) the aldol reaction between 4 and 11 using (-)-Ipc(2)BCl and (ii) the spiroacetalisation, 3 --> 14. Copyright (C) 1996 Elsevier Science Ltd

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页码：8581 / 8584

页数：4

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