Design and synthesis of a highly selective EP4-receptor agonist.: Part 2:: 5-thia and 9β-haloPG derivatives with improved stability

被引：14

作者：

Maruyama, T ^{[1
]}

Asada, M ^{[1
]}

Shiraishi, T ^{[1
]}

Sakata, K ^{[1
]}

Seki, A ^{[1
]}

Yoshida, H ^{[1
]}

Shinagawa, Y ^{[1
]}

Maruyama, T ^{[1
]}

Ohuchida, S ^{[1
]}

Nakai, H ^{[1
]}

Kondo, K ^{[1
]}

Toda, M ^{[1
]}

机构：

[1] Ono Pharmaceut Co Ltd, Minase Res Inst, Mishima, Shizuoka 6188585, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(01)00365-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Further chemical modification to identify more chemically stabilized EP4-receptor selective agonists was continued. As a result, a further two EP4-receptor selective agonists 5-thiaPGE(1) 2a, 10 and 9 beta -chloroPGF(2) analogue 11 were discovered. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2033 / 2035

页数：3

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