Long noncoding RNAs: Novel players in colorectal cancer

被引：293

作者：

Han, Dong ^{[1
,2
]}

Wang, Meng ^{[3
]}

Ma, Ning ^{[1
]}

Xu, Ya ^{[1
]}

Jiang, Yuting ^{[1
]}

Gao, Xu ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Biochem & Mol Biol, Harbin, Peoples R China

[2] Heilongjiang Med Sci Acad, Harbin, Peoples R China

[3] Harbin Med Univ, Affiliated Hosp 2, Dept Gen Surg, Harbin, Peoples R China

来源：

CANCER LETTERS | 2015年 / 361卷 / 01期

关键词：

Long noncoding RNAs; Colorectal cancer (CRC); Tumorigenesis; Therapeutic targets; RANGE CHROMATIN INTERACTIONS; POOR-PROGNOSIS; HEPATOCELLULAR-CARCINOMA; INTEGRATIVE ANNOTATION; REGULATORY SEQUENCES; CELL-PROLIFERATION; EXPRESSION PROFILE; TUMOR-SUPPRESSOR; CODING RNA; CLIP-SEQ;

D O I：

10.1016/j.canlet.2015.03.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Colorectal cancer (CRC) is the most common type of cancer in the world. Despite its commonness, the underlying mechanism of CRC is not completely understood. Long noncoding RNAs (lncRNAs) have received increased attention with the development of whole genome and transcriptome sequencing technologies. Recent findings reveal that lncRNAs are implicated in serial steps of cancer development. These IncRNAs interact with DNA, RNA, protein molecules and/or their combinations, acting as an essential regulator in chromatin organization, and transcriptional and post-transcriptional regulation. In this review, we highlight recent findings of emerging roles for lncRNAs in CRC and discuss rapid translational lncRNA research for clinical application in diagnosis, prognosis and potential treatment. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：13 / 21

页数：9

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