Simultaneous engagement of the activatory receptors NKG2D and CD3 for retargeting of effector cells to CD33-positive malignant cells

被引：32

作者：

Stamova, S. ^{[1
]}

Cartellieri, M. ^{[1
]}

Feldmann, A. ^{[1
]}

Bippes, C. C. ^{[1
]}

Bartsch, H. ^{[1
]}

Wehner, R. ^{[1
]}

Schmitz, M. ^{[1
]}

von Bonin, M. ^{[2
]}

Bornhaeuser, M. ^{[2
]}

Ehninger, G. ^{[2
]}

Rieber, E. P. ^{[1
]}

Bachmann, M. ^{[1
,3
]}

机构：

[1] Tech Univ Dresden, Med Fac Carl Gustav Carus, Inst Immunol, Dresden, Germany

[2] Tech Univ Dresden, Med Fac Carl Gustav Carus, Univ Klinikum Dresden, Med Klin & Poliklin 1, Dresden, Germany

[3] Tech Univ Dresden, Ctr Regenerat Therapies Dresden, Dresden, Germany

来源：

LEUKEMIA | 2011年 / 25卷 / 06期

关键词：

T-CELLS;

D O I：

10.1038/leu.2011.42

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：1053 / 1056

页数：5

共 8 条

[1]

Baeuerle PA, 2009, CURR OPIN MOL THER, V11, P22

[2]

Bross PF, 2001, CLIN CANCER RES, V7, P1490

[3] IDENTIFICATION OF LA RIBONUCLEOPROTEINS AS A COMPONENT OF INTERCHROMATIN GRANULES [J].

CARMOFONSECA, M ;

PFEIFER, K ;

SCHRODER, HC ;

VAZ, MF ;

FONSECA, JE ;

MULLER, WEG ;

BACHMANN, M .

EXPERIMENTAL CELL RESEARCH, 1989, 185 (01) :73-85

[4] Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells [J].

Groh, V ;

Rhinehart, R ;

Randolph-Habecker, J ;

Topp, MS ;

Riddell, SR ;

Spies, T .

NATURE IMMUNOLOGY, 2001, 2 (03) :255-260

[5] TNK cells (NKG2D+ CD8+ or CD4+ T lymphocytes) in the control of human tumors [J].

Maccalli, Cristina ;

Scaramuzza, Samantha ;

Parmiani, Giorgio .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2009, 58 (05) :801-808

[6] Siglecs as targets for therapy in immune-cell-mediated disease [J].

O'Reilly, Mary K. ;

Paulson, James C. .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2009, 30 (05) :240-248

[7] Effective Elimination of Acute Myeloid Leukemic Cells by Recombinant Bispecific Antibody Derivatives Directed Against CD33 and CD16 [J].

Singer, Heiko ;

Kellner, Christian ;

Lanig, Harald ;

Aigner, Michael ;

Stockmeyer, Bernhard ;

Oduncu, Fuat ;

Schwemmlein, Michael ;

Stein, Christoph ;

Mentz, Kristin ;

Mackensen, Andreas ;

Fey, Georg H. .

JOURNAL OF IMMUNOTHERAPY, 2010, 33 (06) :599-608

[8] A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo [J].

von Strandmann, EP ;

Hansen, HP ;

Reiners, KS ;

Schnell, R ;

Borchmann, P ;

Merkert, S ;

Simhadri, VR ;

Draube, A ;

Reiser, M ;

Purr, I ;

Hallek, M ;

Engert, A .

BLOOD, 2006, 107 (05) :1955-1962

← 1 →