Lack of effect of apolipoprotein E E4 allele on neuropsychiatric manifestations in Alzheimer's disease

被引：30

作者：

Hirono, N

Mori, E

Yasuda, M

Imamura, T

Shimomura, T

Hashimoto, M

Tanimukai, S

Kazui, H

Yamashita, H

机构：

[1] Hyogo Inst Aging Brain & Cognit Disorders, Div Clin Neurosci, Himeji, Hyogo 670, Japan

[2] Hyogo Inst Aging Brain & Cognit Disorders, Div Basic Neurosci, Himeji, Hyogo 670, Japan

来源：

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES | 1999年 / 11卷 / 01期

关键词：

D O I：

10.1176/jnp.11.1.66

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The association between the apolipoprotein E epsilon 4 (APOE E4) allele and a wide spectrum of behavioral symptoms of Alzheimer's disease (AD) was investigated. Neither the severity nor the presence of any behavioral changes was associated with the number of APOE E4 alleles, even after controlling for the effects of age at onset, sex, education level, duration of illness, and severity of dementia. The findings do not support the hypothesis that neuropsychiatric manifestations of AD are different in patients with the APOE E4 allele.

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页码：66 / 70

页数：5

相关论文

共 33 条

[1] APOLIPOPROTEIN EPSILON-4 ALLELE AND DISEASE PROGRESSION IN PATIENTS WITH LATE-ONSET ALZHEIMERS-DISEASE [J].

BASUN, H ;

GRUT, M ;

WINBLAD, B ;

LANNFELT, L .

NEUROSCIENCE LETTERS, 1995, 183 (1-2) :32-34

[2] No association between apolipoprotein E genotype and late-onset depression in Alzheimer's disease [J].

Cantillon, M ;

Harwood, D ;

Barker, W ;

GeorgeHyslop, PS ;

Tsuda, T ;

Ekatarina, R ;

Duara, R .

BIOLOGICAL PSYCHIATRY, 1997, 41 (02) :246-248

[3] No difference in cerebral glucose metabolism in patients with Alzheimer disease and differing apolipoprotein E genotypes [J].

Corder, EH ;

Jelic, V ;

Basun, H ;

Lannfelt, L ;

Valind, S ;

Winblad, B ;

Nordberg, A .

ARCHIVES OF NEUROLOGY, 1997, 54 (03) :273-277

[4] APOLIPOPROTEIN-E, SURVIVAL IN ALZHEIMERS-DISEASE PATIENTS, AND THE COMPETING RISKS OF DEATH AND ALZHEIMERS-DISEASE [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

RIMMLER, JB ;

LOCKE, PA ;

CONNEALLY, PM ;

SCHMADER, KE ;

TANZI, RE ;

GUSELLA, JF ;

SMALL, GW ;

ROSES, AD ;

PERICAKVANCE, MA ;

HAINES, JL .

NEUROLOGY, 1995, 45 (07) :1323-1328

[5] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

SCIENCE, 1993, 261 (5123) :921-923

[6] The neuropsychiatric inventory: Assessing psychopathology in dementia patients [J].

Cummings, JL .

NEUROLOGY, 1997, 48 (05) :S10-S16

[7] THE NEUROPSYCHIATRIC INVENTORY - COMPREHENSIVE ASSESSMENT OF PSYCHOPATHOLOGY IN DEMENTIA [J].

CUMMINGS, JL ;

MEGA, M ;

GRAY, K ;

ROSENBERGTHOMPSON, S ;

CARUSI, DA ;

GORNBEIN, J .

NEUROLOGY, 1994, 44 (12) :2308-2314

[8]

CUMMINGS JL, 1990, NEUROPSY NEUROPSY BE, V3, P140

[9]

DalForno G, 1996, ARCH NEUROL-CHICAGO, V53, P345

[10] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

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