Phase/amplitude reset and theta-gamma interaction in the human medial temporal lobe during a continuous word recognition memory task

被引:290
作者
Mormann, F
Fell, J
Axmacher, N
Weber, B
Lehnertz, K
Elger, CE
Fernández, G
机构
[1] Univ Bonn, Dept Epileptol, D-53105 Bonn, Germany
[2] Radboud Univ Nijmegen, FC Donders Ctr Cognit Neuroimaging, Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Dept Neurol, Nijmegen, Netherlands
关键词
event-related potentials; intracranial EEG; epilepsy; theta reset; phase entrainment;
D O I
10.1002/hipo.20117
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We analyzed intracranial electroencephalographic (EEG) recordings from the medial temporal lobes of 12 epilepsy patients during a continuous word recognition paradigm, contrasting trials of correctly recognized repeated words (hits) and correctly identified new words (correct rejections). Using a wavelet-based analysis, we investigated how power changes and phase clustering in different frequency bands contribute to the averaged event-related potentials (ERPs). In addition, we analyzed the actual mean phases of the different oscillations. Our analyses yielded the following results: (1) power changes contributed significantly only to the late components of the ERPs (> 400 ms) (2) earlier ERP components were produced by a stimulus-related broad-band phase and amplitude reset of ongoing oscillatory activity about 190 ms after stimulus onset that involved not only the theta band, but also covered alpha and lower beta band frequencies (3) phase and amplitude reset occurred during an epoch of increased phase entrainment over time that lasted for about two oscillation periods for all involved frequencies and was more pronounced for correct rejections than for hits. The broad-band phase and amplitude reset was observed for both hits and correct rejections, and therefore, did not appear to support a specific cognitive function, but rather to act as a general facilitating factor for the processes involved in this memory task. Further analyses of synchronization between oscillations and power changes in different frequency bands revealed a task-dependent modulation of gamma activity by the entrained theta cycle, a mechanism potentially related to memory encoding and retrieval in the rhinal cortex and hippocampus, respectively. (c) 2005 Wiley-Liss, Inc.
引用
收藏
页码:890 / 900
页数:11
相关论文
共 61 条
[1]   A NEW APPROACH TO ENDOGENOUS EVENT-RELATED POTENTIALS IN MAN - RELATION BETWEEN EEG AND P300-WAVE [J].
BASAR, E ;
BASAREROGLU, C ;
ROSEN, B ;
SCHUTT, A .
INTERNATIONAL JOURNAL OF NEUROSCIENCE, 1984, 24 (01) :1-21
[2]  
BRAGIN A, 1995, J NEUROSCI, V15, P47
[3]  
Bragin A, 1999, HIPPOCAMPUS, V9, P137
[4]   Neuronal oscillations in cortical networks [J].
Buzsáki, G ;
Draguhn, A .
SCIENCE, 2004, 304 (5679) :1926-1929
[5]   2-STAGE MODEL OF MEMORY TRACE FORMATION - A ROLE FOR NOISY BRAIN STATES [J].
BUZSAKI, G .
NEUROSCIENCE, 1989, 31 (03) :551-570
[6]   Theta oscillations in the hippocampus [J].
Buzsáki, G .
NEURON, 2002, 33 (03) :325-340
[7]  
Chrobak JJ, 1998, J NEUROSCI, V18, P388
[8]  
Chrobak JJ, 2000, HIPPOCAMPUS, V10, P457, DOI 10.1002/1098-1063(2000)10:4<457::AID-HIPO12>3.0.CO
[9]  
2-Z
[10]  
DANIELS HE, 1947, BIOMETRIKA, V34, P197, DOI 10.1093/biomet/34.3-4.197