DISC1 and neurocognitive function in schizophrenia

被引：79

作者：

Burdick, KE ^{[1
]}

Hodgkinson, CA

Szeszko, PR

Lencz, T

Ekholm, JM

Kane, JM

Goldman, D

Malhotra, AK

机构：

[1] N Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Dept Psychiat Res, Glen Oaks, NY USA

[2] NIAAA, Neurogenet Lab, Bethesda, MD USA

来源：

NEUROREPORT | 2005年 / 16卷 / 12期

关键词：

DISC1; genetics; neurocognition; schizophrenia;

D O I：

10.1097/01.wnr.0000175248.25535.f6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We recently reported an association between DISC1 and schizophrenia, schizoaffective disorder, and bipolar disorder. Convergent evidence suggests that DISC1 has a direct effect on central nervous system functioning. However, there is a paucity of data investigating the effects of DISC1 on neurocognition. Thus, we analyzed the relationship between five single-nucleotide polymorphisms that influenced risk for schizophrenia in our previous study and neurocognition in 250 patients with schizophrenia. DISC1 genotype was related to neurocognitive performance on measures of rapid visual search and verbal working memory, when controlling for age and premorbid intellectual capacity, and explained 3%-4% of the variance. These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia.

引用

页码：1399 / 1402

页数：4

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