The Inside Out of Lentiviral Vectors

被引：56

作者：

Durand, Stephanie ^{[1
,2
,3
,4
]}

Cimarelli, Andrea ^{[1
,2
,3
,4
]}

机构：

[1] Ecole Normale Super Lyon, Dept Human Virol, F-69364 Lyon, France

[2] INSERM, U758, F-69364 Lyon, France

[3] Univ Lyon 1, F-69364 Lyon, France

[4] BioSci Lyon Gerland IFR128, F-69364 Lyon, France

来源：

VIRUSES-BASEL | 2011年 / 3卷 / 02期

关键词：

lentivirus; lentiviral vector; gene therapy; HIV; SIV; EIAV; FIV; IMMUNODEFICIENCY-VIRUS TYPE-1; INFECTIOUS-ANEMIA VIRUS; REVERSE TRANSCRIPTION COMPLEXES; CENTRAL POLYPURINE TRACT; CENTRAL DNA FLAP; CAPRINE ARTHRITIS-ENCEPHALITIS; GENE-TRANSFER SYSTEMS; PNEUMOCYSTIS-CARINII PNEUMONIA; PERIPHERAL-BLOOD MONOCYTES; IMMUNE-DEFICIENCY SYNDROME;

D O I：

10.3390/v3020132

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Lentiviruses induce a wide variety of pathologies in different animal species. A common feature of the replicative cycle of these viruses is their ability to target non-dividing cells, a property that constitutes an extremely attractive asset in gene therapy. In this review, we shall describe the main basic aspects of the virology of lentiviruses that were exploited to obtain efficient gene transfer vectors. In addition, we shall discuss some of the hurdles that oppose the efficient genetic modification mediated by lentiviral vectors and the strategies that are being developed to circumvent them.

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收藏

页码：132 / 159

页数：28

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