A radioimmunoimaging and MIRD dosimetry treatment planning program for radioimmunotherapy

被引：41

作者：

Erwin, WD

Groch, MW

Macey, DJ

DeNardo, GL

DeNardo, SJ

Shen, S

机构：

[1] NORTHWESTERN MEM HOSP, DEPT NUCL MED, CHICAGO, IL 60611 USA

[2] MD ANDERSON CANC CTR, DEPT RADIAT PHYS, HOUSTON, TX 77030 USA

[3] UNIV CALIF DAVIS, MED CTR, DEPT INTERNAL MED, SACRAMENTO, CA 95816 USA

[4] UNIV CALIF DAVIS, MED CTR, DEPT RADIOL, SACRAMENTO, CA 95816 USA

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1996年 / 23卷 / 04期

关键词：

dosimetry; MIRD; monoclonal antibodies; radioimmunoimaging; radioimmunotherapy; treatment planning;

D O I：

10.1016/0969-8051(96)00036-4

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A treatment planning program for radioimmunotherapy employing quantitative Anger camera imaging and the MIRD formalism has been designed and implemented on a clinical nuclear medicine computer. Radionuclide residence times are calculated from linear, mono- and bi exponential, and cubic spline fits to regional activity versus time curves, and radiation-absorbed dose estimates for all target organs for I-131, Cu-67, and 58 other radionuclides can be calculated. This software has been successfully applied to radioimmunotherapy of B-cell malignancies and breast adenocarcinomas.

引用

页码：525 / 532

页数：8

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