Thermoresponsive nanostructures by self-assembly of a poly(N-isopropylacrylamide)-lipid conjugate

被引:39
作者
Hay, DNT
Rickert, PG
Seifert, S
Firestone, MA
机构
[1] Argonne Natl Lab, Div Mat Sci, Argonne, IL 60439 USA
[2] Argonne Natl Lab, Div Chem, Argonne, IL 60439 USA
[3] Argonne Natl Lab, Adv Photon Source Div, Argonne, IL 60439 USA
关键词
D O I
10.1021/ja039023e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The synthesis and purification of a poly(N-isopropylacrylamide)?lipid conjugate and its use in the preparation of a thermoresponsive lipid mesophase is described. Specifically, poly(N-isopropylacrylamide) with a single carboxyl group at one end was activated with dicyclohexylcarbodiimide/N-hydroxysuccinimide to form an active ester. This N-hydroxysuccinimide ester was then used to form a dimyristoyl-sn-glycero-3-phosphoethanolamine conjugate with poly(N-isopropylacrylamide) via an amide bond, rendering the conjugate amphiphilic. Quaternary phases comprising the conjugate, a phosopholipid, dimyristoylphosphatidylcholine, and a cosurfactant, N,N-dimethyldodecylamine-N-oxide, dispersed in water were found to self-assemble at room temperature to form liquid crystalline gels, adopting an expanded lamellar structure. A modest increase in temperature triggered the reversible conversion of the aggregate to a collapsed lamellar structure, while a modest reduction in temperature resulted in its conversion to a nonlamellar phase. The phases were characterized by polarized optical microscopy and small-angle X-ray scattering (SAXS). Copyright © 2004 American Chemical Society.
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页码:2290 / 2291
页数:2
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