Asymmetric catalysis of ene reactions with trifluoropyruvate catalyzed by dicationic palladium(II) complexes

被引：70

作者：

Aikawa, K ^{[1
]}

Kainuma, S ^{[1
]}

Hatano, M ^{[1
]}

Mikami, K ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Appl Chem, Meguro Ku, Tokyo 1528552, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 01期

关键词：

carbonyl-ene reaction; palladium; BINAP; SEGPHOS; trifluoropyruvate;

D O I：

10.1016/j.tetlet.2003.10.137

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chiral dicationic SEGPHOS-Pd(II) complex achieves a high chemical yield, (E)-olefin selectivity, anti-diastereoselectivity, along with high enantioselectivity even with less reactive mono- and 1,2-disubstituted olefins in this much less reactive ketoneene reactions. The high levels of enantio selectivity stem from the effective shielding with diphenyl groups on phosphines caused by the narrow dihedral angle of metal complexes with SEGPHOS. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：183 / 185

页数：3

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