Δ9-THC Intoxication by Cannabidiol-Enriched Cannabis Extract in Two Children with Refractory Epilepsy: Full Remission after Switching to Purified Cannabidiol

被引:50
作者
Crippa, Jose A. S. [1 ]
Crippa, Ana C. S. [2 ]
Hallak, Jaime E. C. [1 ]
Martin-Santos, Rocio [1 ,3 ,4 ]
Zuardi, Antonio W. [1 ]
机构
[1] Univ Sao Paulo, Dept Neurosci & Behav, Ribeirao Preto, Brazil
[2] Univ Fed Parana, Dept Clin Med, Curitiba, Parana, Brazil
[3] Univ Barcelona, Hosp Clin, August Pi & Sunyer Biomed Res Inst, Inst Neurosci,Ctr Biomed Res Mental Hlth Network, Barcelona, Spain
[4] Univ Barcelona, Dept Med, Barcelona, Spain
来源
FRONTIERS IN PHARMACOLOGY | 2016年 / 7卷
关键词
cannabidiol; epilepsy; Cbd; intoxication; refractory reriod; electrophysiological; TREATMENT-RESISTANT EPILEPSY; PEDIATRIC EPILEPSY; HEALTHY-VOLUNTEERS; MEDICAL CANNABIS; DRUG; NEUROGENESIS; PRODUCTS; NEURONS;
D O I
10.3389/fphar.2016.00359
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Animal studies and preliminary clinical trials have shown that cannabidiol (CBD)-enriched extracts may have beneficial effects for children with treatment-resistant epilepsy. However, these compounds are not yet registered as medicines by regulatory agencies. We describe the cases of two children with treatment-resistant epilepsy (Case A with left frontal dysplasia and Case B with Dravet Syndrome) with initial symptom improvement after the introduction of CBD extracts followed by seizure worsening after a short time. The children presented typical signs of intoxication by Delta 9-THC (inappropriate laughter, ataxia, reduced attention, and eye redness) after using a CBD-enriched extract. The extract was replaced by the same dose of purified CBD with no Delta 9-THC in both cases, which led to improvement in intoxication signs and seizure remission. These cases support pre-clinical and preliminary clinical evidence suggesting that CBD may be effective for some patients with epilepsy. Moreover, the cases highlight the need for randomized clinical trials using high-quality and reliable substances to ascertain the safety and efficacy of cannabinoids as medicines.
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页数:6
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