Effects of air pollutants on innate immunity: The role of Toll-like receptors and nucleotide-binding oligomerization domain-like receptors

被引：150

作者：

Bauer, Rebecca N. ^{[1
]}

Diaz-Sanchez, David ^{[4
]}

Jaspers, Ilona ^{[1
,2
,3
]}

机构：

[1] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27515 USA

[2] Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA

[3] Univ N Carolina, Dept Pediat, Chapel Hill, NC USA

[4] US EPA, Natl Hlth & Environm Effects, Res Lab, Res Triangle Pk, NC 27711 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2012年 / 129卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Toll-like receptor; NOD-like receptor; pattern recognition receptor; inflammasome; cigarette smoke; particulate matter; ozone; diesel exhaust; nanoparticles; air pollutant; innate immunity; host defense; pathogen-associated molecular pattern; danger-associated molecular pattern; lung; airway; PATTERN-RECOGNITION RECEPTORS; PLASMACYTOID DENDRITIC CELLS; DIESEL EXHAUST PARTICLES; EPITHELIAL-CELLS; NLRP3; INFLAMMASOME; NALP3; OZONE EXPOSURE; LUNG HYPERPERMEABILITY; PULMONARY INFLAMMATION; HOSPITAL ADMISSIONS;

D O I：

10.1016/j.jaci.2011.11.004

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Interactions between exposure to ambient air pollutants and respiratory pathogens have been shown to modify respiratory immune responses. Emerging data suggest key roles for Toll-like receptor (TLR) and nucleotide-binding oligomerization domain-like receptor (NLR) signaling in pathogen-induced immune responses. Similarly, immune responses elicited by exposure to air pollutants are mediated by specific TLR- and NLR-dependent mechanisms. This review article will summarize current knowledge about how air pollutants modify TLR-and NLR-dependent signaling and host defense responses in the lung. (J Allergy Clin Immunol 2012; 129: 14-24.)

引用

页码：14 / 26

页数：13

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