In Vitro Resistance Profile of the Hepatitis C Virus NS3 Protease Inhibitor BI 201335

被引：43

作者：

Lagace, Lisette ^{[1
]}

White, Peter W. ^{[1
]}

Bousquet, Christiane ^{[1
]}

Dansereau, Nathalie ^{[1
]}

Do, Florence ^{[1
]}

Llinas-Brunet, Montse ^{[1
]}

Marquis, Martin ^{[1
]}

Massariol, Marie-Josee ^{[1
]}

Maurice, Roger ^{[1
]}

Spickler, Catherine ^{[1
]}

Thibeault, Diane ^{[1
]}

Triki, Ibtissem ^{[1
]}

Zhao, Songping ^{[1
]}

Kukolj, George ^{[1
]}

机构：

[1] Boehringer Ingelheim Canada Ltd, Quebec City, PQ H7S 2G5, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 01期

关键词：

TELAPREVIR; SENSITIVITY; BOCEPREVIR; THERAPIES; VARIANTS; BINDING; VX-950; TMC435;

D O I：

10.1128/AAC.05166-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

The in vitro resistance profile of BI 201335 was evaluated through selection and characterization of variants in genotype 1a (GT 1a) and genotype 1b (GT 1b) replicons. NS3 R155K and D168V were the most frequently observed resistant variants. Phenotypic characterization of the mutants revealed shifts in sensitivity specific to BI 201335 that did not alter susceptibility to alpha interferon. In contrast to macrocyclic and covalent protease inhibitors, changes at V36, T54, F43, and Q80 did not confer resistance to BI 201335.

引用

页码：569 / 572

页数：4

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