Crystal structure of human cathepsin K complexed with a potent inhibitor

被引：146

作者：

McGrath, ME

Klaus, JL

Barnes, MG

Bromme, D

机构：

[1] Arris Pharmaceutical, South San Francisco, CA 94080

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 02期

关键词：

D O I：

10.1038/nsb0297-105

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The high resolution structure of the new therapeutic target, cathepsin K, complexed with the potent mechanism-based inhibitor, APC3328, reveals the substrate-binding sites of this cysteine proteinase and validates the binding mode for this inhibitor class.

引用

页码：105 / 109

页数：5

共 34 条

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