Regression of an unresectable pancreatic tumor following nonmyeloablative allogeneic peripheral-blood stem-cell transplantation

被引：21

作者：

Omuro, Y

Matsumoto, G

Sasaki, T

Tanaka, Y

Maeda, Y

Sakamaki, H

Hiruma, K

Tsuruta, K

Takahashi, T

机构：

[1] Tokyo Metropolitan Komagome Hosp, Dept Chemotherapy, Bunkyo Ku, Tokyo 1138677, Japan

[2] Tokyo Metropolitan Komagome Hosp, Dept Surg, Bunkyo Ku, Tokyo 1138677, Japan

[3] Tokyo Metropolitan Komagome Hosp, Dept Hematol, Bunkyo Ku, Tokyo 1138677, Japan

[4] Tokyo Metropolitan Komagome Hosp, Dept Transfus Med, Bunkyo Ku, Tokyo 1138677, Japan

[5] Tokyo Metropolitan Komagome Hosp, Tokyo, Japan

来源：

BONE MARROW TRANSPLANTATION | 2003年 / 31卷 / 10期

关键词：

non-myeloablative allogeneic stem cell transplantation; graft-versus-tumor effect; pancreatic tumor;

D O I：

10.1038/sj.bmt.1703932

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A 59-year-old female with an unresectable, large pancreatic tumor (10.0 x 8.0 cm(2) on CT scan) underwent nonmyeloablative allogeneic peripheral-blood stem-cell transplantation from her HLA-identical sibling. Pronounced tumor regression and relief from pain without acute graft-versus-host disease (GVHD) were observed following transplantation. The patient is surviving (more than 300 days) after transplantation, with extensive chronic GVHD, and has tumor regression with an 80% reduction in tumor size. The observed clinical course may suggest a graft-versus-tumor effect on the pancreatic tumor following allogeneic stem-cell transplantation.

引用

页码：943 / 945

页数：3

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