Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics

被引:278
作者
Dayan, AD [1 ]
机构
[1] WHO, Parasit Dis & Vector Control, PVC, Communicable Dis Control Prevent & Eradicat,CPE, CH-1211 Geneva 27, Switzerland
[2] Queen Mary Univ London, Fac Med, London E1 4NS, England
关键词
albendazole; mebendazole; praziquantel; toxicity; pharmacokinetics; risk assessment;
D O I
10.1016/S0001-706X(03)00031-7
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The pharmacokinetics and toxicity of albendazole, mebendazole and praziquantel are extensively reviewed, drawing on original published work and reviews in the open scientific literature and on assessments by international agencies and official regulatory bodies in Europe and the USA. Information about human and veterinary medical uses and adverse reactions is evaluated. The totality of the non-clinical information available about these long-established drugs may not comply with current official guidelines for new medicines but reasons are given why the "deficiencies" are only apparent and the data gaps can be replaced by other results, largely obtained from the target species and the many years of clinical experience of safe use of these drugs in humans and animals. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:141 / 159
页数:19
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