Acute loss of intestinal CD4+ T cells is not predictive of simian immunodeficiency virus virulence

被引:193
作者
Pandrea, Ivona V.
Gautam, Rajeev
Ribeiro, Ruy M.
Brenchley, Jason M.
Butler, Isolde F.
Pattison, Melissa
Rasmussen, Terri
Marx, Preston A.
Silvestri, Guido
Lackner, Andrew A.
Perelson, Alan S.
Douek, Daniel C.
Veazey, Ronald S.
Apetrei, Cristian
机构
[1] Tulane Natl Primate Res Ctr, Covington, LA 70433 USA
[2] Tulane Univ, Sch Publ Hlth, Dept Trop Med, New Orleans, LA 70112 USA
[3] Tulane Univ, Sch Med, Dept Microbiol & Immunol, New Orleans, LA 70112 USA
[4] Tulane Univ, Sch Med, Dept Pathol, New Orleans, LA 70112 USA
[5] Los Alamos Natl Lab, Los Alamos, NM 87545 USA
[6] NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA
[7] Univ Penn, Sch Med, Dept Pathol, Philadelphia, PA 19107 USA
关键词
D O I
10.4049/jimmunol.179.5.3035
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The predictive value of acute gut-associated lymphoid tissue (GALT) CD4(+) T cell depletion in lentiviral infections was assessed by comparing three animal models illustrative of the outcomes of SIV infection: pathogenic infection (SIVsmm infection of rhesus macaques (Rh)), persistent nonprogressive infection (SIVagm infection of African green monkeys (AGM)), and transient, controlled infection (SIVagm infection of Rh). Massive acute depletion of GALT CD4(+) T cells was a common feature of acute SIV infection in all three models. The outcome of this mucosal CD4(+) T cell depletion, however, differed substantially between the three models: in SIVsmm-infected Rh, the acute GALT CD4(+) T cell depletion was persistent and continued with disease progression; in SIVagm, intestinal CD4(+) T cells were partially restored during chronic infection in the context of normal levels of apoptosis and immune activation and absence of damage to the mucosal immunologic barrier; in SIVagm-infected Rh, complete control of viral replication resulted in restoration of the mucosal barrier and immune restoration. Therefore, our data support a revised paradigm wherein severe GALT CD4(+) T cell depletion during acute pathogenic HIV and SIV infections of humans and Rh is necessary but neither sufficient nor predictive of disease progression, with levels of immune activation, proliferation and apoptosis being key factors involved in determining progression to AIDS.
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收藏
页码:3035 / 3046
页数:12
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