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The insulin-like growth factor 1 receptor in cancer: Old focus, new future

被引：144
作者：
Hartog, Hermien
Wesseling, Jelle
Boezen, H. Marike
van der Graaf, Winette T. A.
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Med Oncol, NL-6500 HB Nijmegen, Netherlands
[2] Univ Groningen, Med Ctr, Dept Oncol, Groningen, Netherlands
[3] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Pathol, Amsterdam, Netherlands
[4] Univ Groningen, Med Ctr, Dept Epidemiol, Groningen, Netherlands
来源：
EUROPEAN JOURNAL OF CANCER | 2007年 / 43卷 / 13期
关键词：
insulin-like growth factor 1 receptor; insulin receptor; hybrid receptor; tyrosine kinase inhibitors; targeted therapy; growth factor receptor; antibody; cancer;
D O I：
10.1016/j.ejca.2007.05.021
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The importance of insulin-like growth factor I receptor (IGF-1R) signalling in malignant behaviour of tumour cells is well established. Currently, development of drugs targeting the IGF-1R as anticancer treatment is emerging. Several IGF-1R targeting strategies are being investigated in phases 1 and 11 clinical trials. interactions of IGF-1R with insulin receptor, however, might complicate efficiency and tolerability of such drugs. This review describes mechanisms, recent developments and potential limitations of IGF-1R antibodies and tyrosine kinase inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.
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页码：1895 / 1904
页数：10
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