Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and macro-albuminuria and progression of diabetic nephropathy among Iranians with type 2 diabetes mellitus

被引：41

作者：

Rahimi, Mehrali ^{[2
]}

Hasanvand, Ali ^{[3
]}

Rahimi, Zohreh ^{[1
,4
,5
]}

Vaisi-Raygani, Asad ^{[6
]}

Mozafari, Hadi

Rezaei, Mansour ^{[4
]}

Zargooshi, Javad ^{[4
]}

Najafi, Farid ^{[4
]}

Shakiba, Ebrahim ^{[5
]}

机构：

[1] Kermanshah Univ Med Sci, Sch Med, Med Biol Res Ctr, Kermanshah, Iran

[2] Kermanshah Univ Med Sci, Sch Med, Dept Endocrinol, Kermanshah, Iran

[3] Kermanshah Univ Med Sci, Sch Pharm, Dept Pharmacol, Kermanshah, Iran

[4] Kermanshah Univ Med Sci, Rhazes Ctr Res Family Hlth & Sexual Med, Kermanshah, Iran

[5] Kermanshah Univ Med Sci, Sch Med, Dept Biochem, Kermanshah, Iran

[6] Kermanshah Univ Med Sci, Fertil & Infertil Res Ctr, Kermanshah, Iran

来源：

CLINICAL BIOCHEMISTRY | 2010年 / 43卷 / 16-17期

关键词：

MTHFR C677T MTHFR A1298C; Microalbuminuria; Macroalbuminuria; Type 2 diabetes mellitus; Western Iran; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; CORONARY-ARTERY-DISEASE; ASSOCIATION; HYPERHOMOCYSTEINEMIA; MACROANGIOPATHY; PREVALENCE; GENOTYPE; VARIANT;

D O I：

10.1016/j.clinbiochem.2010.08.019

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Objectives: To find whether polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C are risk factors for diabetic nephropathy (DN) among type 2 diabetes mellitus (T2DM) patients from Western Iran. Design and methods: The MTHFR polymorphisms were detected in 72 microalbuminuric, 68 macroalbuminuric and 72 normoalbuinuric T2DM patients by PCR-RFLP. Results: The possession of both MTHFR 677T and 1298C alleles increase the risk of microalbuminuria to 4.3-fold (p = 0.007) in 12DM patients. The presence of either MTHFR 677T, 1298C allele is sufficient to increase the risk of macroalbuminuria in T2DM patients by 4.1 and 5.5 times (p = 0.027, and p = 0.006, respectively). The concomitant presence of both 677T and 1298C alleles act in synergy to increase the risk of macroalbuminuria by 20.4-fold (p<0.001) and progression of DN from microalbuminuria to macroalbuminuria (OR=4.73, p=0.01). Conclusion: Both MTHFR 677T and 1298C alleles increased the susceptibility to the onset and progression of DN in Iranians with T2DM. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1333 / 1339

页数：7

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