The results of an mtDNA study of 1200 inhabitants of a German village in comparison to other Caucasian databases and its relevance for forensic casework

被引：40

作者：

Pfeiffer, H

Forster, P

Ortmann, C

Brinkmann, B

机构：

[1] Univ Munster, Inst Legal Med, D-48149 Munster, Germany

[2] Univ Cambridge, McDonald Inst Archaeol Res, Cambridge CB2 3ER, England

来源：

INTERNATIONAL JOURNAL OF LEGAL MEDICINE | 2001年 / 114卷 / 03期

关键词：

mitochondrial DNA; hypervariable region 1; forensic science;

D O I：

10.1007/s004140000165

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Mitochondrial DNA control region sequences were determined in 1200 male volunteers from one village area of Lower Saxony for the hypervariable region 1 (HV1). The 154 variable positions found resulted in 460 different haplotypes with a haplotype diversity value of 0.98165. The number of different haplotypes showed a nearly linear increase with the number of individuals typed. The haplotype diversity approached saturation level at a value of approximately 0.981 after typing 400 individuals. Furthermore, the number of different haplotypes and the haplotype diversity were calculated for four short amplicons of HV1 in order to establish the most variable section with a high efficiency for forensic casework.

引用

页码：169 / 172

页数：4

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