The human Y chromosome: An evolutionary marker comes of age

被引:649
作者
Jobling, MA
Tyler-Smith, C
机构
[1] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England
[2] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
基金
英国惠康基金;
关键词
D O I
10.1038/nrg1124
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Until recently, the Y chromosome seemed to fulfil the role of juvenile delinquent among human chromosomes - rich in junk, poor in useful attributes, reluctant to socialize with its neighbours and with an inescapable tendency to degenerate. The availability of the near-complete chromosome sequence, plus many new polymorphisms, a highly resolved phylogeny and insights into its mutation processes, now provide new avenues for investigating human evolution. Y-chromosome research is growing up.
引用
收藏
页码:598 / 612
页数:15
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