Neuronal 'On' and 'Off' signals control microglia

被引：589

作者：

Biber, Knut ^{[1
]}

Neumann, Harald

Inoue, Kazuhide

Boddeke, Hendrikus W. G. M.

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Med Physiol, NL-9713 AV Groningen, Netherlands

[2] Univ Bonn, Life & Brain Ctr, Inst Reconstruct Neurobiol, D-53127 Bonn, Germany

[3] Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Mol & Syst Pharmacol, Fukuoka 8128582, Japan

来源：

TRENDS IN NEUROSCIENCES | 2007年 / 30卷 / 11期

关键词：

D O I：

10.1016/j.tins.2007.08.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent findings indicate that neurons are not merely passive targets of microglia but rather control microglial activity. The variety of different signals that neurons use to control microglia can be divided into two categories: 'Off' signals constitutively keep microglia in their resting state and antagonize proinflammatory activity. 'On' signals are inducible and include purines, chemokines, glutamate. They instruct microglia activation under pathological conditions towards a beneficial or detrimental phenotype. Various neuronal signaling molecules thus actively control microglia function, thereby contribute to the inflammatory milieu of the central nervous system. Thus, neurons should be envisaged as key immune modulators in the brain.

引用

页码：596 / 602

页数：7

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