BDNF dependence in neuroblastoma

被引：33

作者：

Feng, X ^{[1
]}

Jiang, H ^{[1
]}

Baik, JC ^{[1
]}

Edgar, C ^{[1
]}

Eide, FF ^{[1
]}

机构：

[1] Univ Chicago, Dept Neurol, Chicago, IL 60637 USA

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2001年 / 64卷 / 04期

关键词：

adenovirus; apoptosis; cancer; differentiation; neurotrophin;

D O I：

10.1002/jnr.1086

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuroblastomas are heterogeneous tumors arising from sympathetic precursors in the neural crest. Growth factor stimulation of neuroblastomas promote diverse biological responses (mitogenesis, differentiation, cell death) depending on the particular tumor studied. Here we show that brief treatment with retinoic acid (RA) rendered the human neuroblastoma lines SY5Y, NGP, SMS-KCNR, and SK-N-SH dependent on brain-derived neurotrophic factor (BDNF) for survival. The BDNF- and trkB-expressing line SMS-KCN was dependent on an autocrine BDNF/trkB survival without exposure to RA. We conclude that the BDNF/trkB pathway plays an important role in neuroblastoma survival and speculate on a possible role in tumor pathogenesis. (C) 2001 Wiley-Liss, Inc.

引用

页码：355 / 363

页数：9

共 47 条

[1] A BDNF AUTOCRINE LOOP IN ADULT SENSORY NEURONS PREVENTS CELL DEATH [J].