Transmission of antibodies from mother to young: Evolutionary strategies in a proteolytic environment

被引:66
作者
Baintner, Karoly [1 ]
机构
[1] Univ Kaposvar, Fac Anim Sci, Dept Physiol, H-7401 Kaposvar, Hungary
关键词
FcRn; vacuole; antibody; yolk sac; mammary gland; placenta; small intestine; proteolysis; colostrum; mammals; NEONATAL FC-RECEPTOR; ILEAL EPITHELIAL-CELLS; HUMAN FETAL INTESTINE; YOLK-SAC ENDODERM; MAMMARY-GLAND; IMMUNOGLOBULIN-G; IGG RECEPTORS; POLYVINYL PYRROLIDONE; MECONIUM CORPUSCLES; MEDIATED TRANSPORT;
D O I
10.1016/j.vetimm.2007.03.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Transmission of antibody from mother to young is an essential process. Maternal proteins provide both food (if digested) and immune protection (undigested antibody) for the offspring. The processes for transfer changed and diversified during vertebrate evolution, using receptor-dependent and -independent mechanisms pre- and postnatally. Transmission frequently proceeds in a proteolytic environment and different mechanisms evolved for the protection of antibody. The present review focuses on the relationship of acquisition of passive immunity to other physiological processes. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:153 / 161
页数:9
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