High-level acetaldehyde production in Lactococcus lactic by metabolic engineering

被引：58

作者：

Bongers, RS

Hoefnagel, MHN

Kleerebezem, M

机构：

[1] NIZO Food Res, Dept Flavour & Nat Ingredients, NL-6710 BA Ede, Netherlands

[2] NIZO Food Res, Wageningen Ctr Food Sci, NL-6710 BA Ede, Netherlands

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2005年 / 71卷 / 02期

关键词：

D O I：

10.1128/AEM.71.2.1109-1113.2005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Efficient conversion of glucose to acetaldehyde is achieved by nisin-controlled overexpression of Zymomonas mobilis pyruvate decarboxylase (pdc) and Lactococcus lactis NADH oxidase (nox) in L. lactis. In resting cells, almost 50% of the glucose consumed could be redirected towards acetaldehyde by combined overexpression of pdc and nox under anaerobic conditions.

引用

收藏

页码：1109 / 1113

页数：5

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