Total synthesis and structural elucidation of (-)-delactonmycin

被引：22

作者：

Correa, IR ^{[1
]}

Pilli, RA ^{[1
]}

机构：

[1] Univ Estadual Campinas, UNICAMP, Inst Quim, BR-13084971 Campinas, SP, Brazil

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 26期

关键词：

antiviral agents; natural products; structure elucidation; total synthesis; Wittig reactions;

D O I：

10.1002/anie.200351347

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The key steps in the total synthesis of delactonmycin (1) involved a Wittig olefination, a Negishi coupling, and an aldol reaction. The polyketide, which was isolated from Streptomyces sp., displays potent inhibitory activity of the nucleocytoplasmic translocation of the HIV-1 regulatory protein Rev.

引用

页码：3017 / 3020

页数：4

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