RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo

被引：51

作者：

Chen, Yangchao ^{[1
]}

Xie, Dan ^{[2
]}

Li, Wing Yin

Cheung, Chi Man

Yao, Hong ^{[3
,4
]}

Chan, Ching Yu

Chan, Chu-yan ^{[3
,4
]}

Xu, Fang-Ping ^{[5
]}

Liu, Yan-Hui ^{[5
]}

Sung, Joseph J. Y. ^{[6
]}

Kung, Hsiang-fu ^{[3
,4
]}

机构：

[1] Chinese Univ Hong Kong, Sci Ctr N, Fac Med & Therapeut, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China

[2] Sun Yat Sen Univ, State Key Lab Oncol S China, Ctr Canc, Guangzhou 510275, Guangdong, Peoples R China

[3] Chinese Univ Hong Kong, Stanley Ho Ctr Emerging Infect Dis, Shatin, Hong Kong, Peoples R China

[4] Chinese Univ Hong Kong, State Key Lab Oncol S China, Shatin, Hong Kong, Peoples R China

[5] Guangdong Prov Peoples Hosp, Dept Pathol, Guangzhou, Guangdong, Peoples R China

[6] Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China

来源：

CANCER LETTERS | 2010年 / 297卷 / 01期

关键词：

Enhancer of zeste homolog 2; Pancreatic cancer; Tumorigenecity; Liver metastasis; GROUP PROTEIN EZH2; POPULATION-BASED ANALYSIS; POLYCOMB-GROUP PROTEINS; OF-DEFENSE HOSPITALS; HEPATOCELLULAR-CARCINOMA; HEPATIC METASTASIS; DOWN-REGULATION; BREAST-CANCER; NUDE-MICE; EXPRESSION;

D O I：

10.1016/j.canlet.2010.05.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The function of EZH2 in tumorigenesis and liver metastasis of pancreatic cancer has never been elucidated in vivo. EZH2 was overexpressed in pancreatic carcinomas and its overexpression was associated with tumor differentiation and pT status. Suppression of EZH2 caused a significant growth inhibition of pancreatic cancer cells in vitro and markedly diminished their tumorigenicity in vivo. Knock-down of EZH2 inhibited liver metastasis of pancreatic cancer in vivo. EZH2 has a crucial role in tumor growth and liver metastasis of pancreatic cancer. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：109 / 116

页数：8

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