Metabolic Syndrome and the Genesis of Uric Acid Stones

被引：77

作者：

Maalouf, Naim M. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Charles & Jane Pak Ctr Mineral Metab & Clin Res, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

来源：

JOURNAL OF RENAL NUTRITION | 2011年 / 21卷 / 01期

关键词：

BIOCHEMICAL PROFILE; DIABETES-MELLITUS; RISK-FACTORS; NEPHROLITHIASIS; PROTEIN; DIETS; PH;

D O I：

10.1053/j.jrn.2010.10.015

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Uric acid stones are significantly more common among nephrolithiasis patients with type 2 diabetes, obesity, and/or the metabolic syndrome. The principal metabolic feature responsible for this association is an overly acidic urine, which leads to the precipitation of sparingly soluble uric acid crystals in urine and subsequent development of stones. The unduly acidic urine in uric acid stone formers is caused by a combination of excessive dietary intake of animal proteins and a defect in renal ammoniagenesis and/or excretion that leads to impaired buffering and amplifies the acidic urine caused by an increased acid excretion. (C) 2011 by the National Kidney Foundation, Inc. All rights reserved.

引用

收藏

页码：128 / 131

页数：4

相关论文

共 17 条

[1]

The metabolic syndrome and uric acid nephrolithiasis: Novel features of renal manifestation of insulin resistance [J].

Abate, N ;

Chandalia, M ;

Cabo-Chan, AV ;

Moe, OW ;

Sakhaee, K .

KIDNEY INTERNATIONAL, 2004, 65 (02) :386-392

[2]

Urine composition in type 2 diabetes: Predisposition to uric acid nephrolithiasis [J].

Cameron, MA ;

Maalouf, NM ;

Adams-Huet, B ;

Moe, OW ;

Sakhaee, K .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (05) :1422-1428

[3]

Type 2 diabetes increases the risk for uric acid stones [J].

Daudon, M ;

Traxer, O ;

Conort, P ;

Lacour, B ;

Jungers, P .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (07) :2026-2033

[4]

Influence of body size on urinary stone composition in men and women [J].

Daudon, M ;

Lacour, B ;

Jungers, P .

UROLOGICAL RESEARCH, 2006, 34 (03) :193-199

[5]

Metabolic risk factors and the impact of medical therapy on the management of nephrolithiasis in obese patients [J].

Ekeruo, WO ;

Tan, YH ;

Young, MD ;

Dahm, P ;

Maloney, ME ;

Mathias, BJ ;

Albala, DM ;

Preminger, GM .

JOURNAL OF UROLOGY, 2004, 172 (01) :159-163

[6]

THE INFLUENCE OF A HIGH DIETARY-INTAKE OF PURINE-RICH ANIMAL PROTEIN ON URINARY URATE EXCRETION AND SUPERSATURATION IN RENAL STONE DISEASE [J].

FELLSTROM, B ;

DANIELSON, BG ;

KARLSTROM, B ;

LITHELL, H ;

LJUNGHALL, S ;

VESSBY, B .

CLINICAL SCIENCE, 1983, 64 (04) :399-405

[7]

Diabetes mellitus and the risk of urinary tract stones: A population-based case-control study [J].

Lieske, John C. ;

de la Vega, Lourdes S. Pena ;

Gettman, Matthew T. ;

Slezak, Jeffrey M. ;

Bergstralh, Eric J. ;

Melton, Joseph, III ;

Leibson, Cynthia L. .

AMERICAN JOURNAL OF KIDNEY DISEASES, 2006, 48 (06) :897-904

[8]

Low urine pH: A novel feature of the metabolic syndrome [J].

Maalouf, Naim M. ;

Cameron, Mary Ann ;

Moe, Orson W. ;

Adams-Huet, Beverley ;

Sakhaee, Khashayar .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2007, 2 (05) :883-888

[9]

Novel insights into the pathogenesis of uric acid nephrolithiasis [J].

Maalouf, NM ;

Cameron, MA ;

Moe, OW ;

Sakhaee, K .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2004, 13 (02) :181-189

[10]

Association of urinary pH with body weight in nephrolithiasis [J].

Maalouf, NM ;

Sakhaee, K ;

Parks, JH ;

Coe, FL ;

Adams-Huet, B ;

Pak, CYC .

KIDNEY INTERNATIONAL, 2004, 65 (04) :1422-1425