Expression of alpha-defensin-1 in chronic hyperplastic candidosis

被引:3
作者
Ali, A
Niissalo, S
Hietanen, J
Laine, M
Rautemaa, R
Konttinen, Y
机构
[1] Univ Helsinki, Dept Anat Biomedicum, Helsinki, Finland
[2] Univ Helsinki, Dept Oral Pathol, Inst Dent, Helsinki, Finland
[3] Univ Helsinki, Cent Hosp, Oral Pathol Unit Lab Diagnost, Helsinki, Finland
[4] Univ Helsinki, Inst Dent, Helsinki, Finland
[5] Univ Helsinki, Cent Hosp, Microbiol Unit Lab Diagnost, Helsinki, Finland
[6] Univ Helsinki, Dept Bacteriol & Immunol, Haartman Inst, Helsinki, Finland
[7] Univ Helsinki, Cent Hosp, Dept Med Invartes Med, Helsinki, Finland
[8] ORTON Orthopaed Hosp Invalid Fdn, Helsinki, Finland
[9] COXA Joint Replacement Hosp, Tampere, Finland
关键词
alpha-defensin-1; candida; neutrophil;
D O I
10.1111/j.1600-0714.2005.00317.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
BACKGROUND: Chronic hyperplastic candidosis (CHC) represents a chronic opportunistic candida infection. We clarified the presence, localization and participation of alpha-defensin-1 in host response against chronic candidal stimulus. METHOS: Immunohistochemically stained CHC biopsies (n = 10) were compared to candida negative idiopathic leukoplakia (n = 10). RESULTS: In CHC alpha-defensin-1 was detected in neutrophils intravascularly, in lamina propria and in the epithelium, in part in intraepithelial microabscesses. Staining intensity of individual neutrophils varied and was associated with peri- and extracellular staining, in particular in the superficial epithelial cell layers. In controls only very few homogeneously staining neutrophils were detected intravascularly without any extracellular alpha-defensin-1 deposition. CONCLUSIONS: Neutrophils form microabscesses and respond to Candida by activation and release of alpha-defensin-1 to peri- and extracellular matrix. This together with the epithelial cell migration from the basal layer to epithelial surface leads to alpha-defensin-1 rich protective shield in the most superficial epithelial cell layers.
引用
收藏
页码:347 / 351
页数:5
相关论文
共 10 条