The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters

被引：70

作者：

Huyck, Karen L. ^{[9
]}

Panhuysen, Carolien I. M. ^{[10
]}

Cuenco, Karen T. ^{[10
]}

Zhang, Jingmei ^{[10
]}

Goldhammer, Hilary ^{[1
,2
,3
]}

Jones, Emlyn S. ^{[1
,2
,3
]}

Somasundaram, Priya ^{[1
,2
,3
]}

Lynch, Allison M. ^{[1
,2
,3
]}

Harlow, Bernard L. ^{[1
,2
,3
,5
]}

Lee, Hang ^{[6
,7
,8
]}

Stewart, Elizabeth A. ^{[1
,2
,3
]}

Morton, Cynthia C. ^{[1
,2
,3
,4
]}

机构：

[1] Brigham & Womens Hosp, Dept Obstet, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Gynecol, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Reprod Biol, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[5] Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, Boston, MA 02115 USA

[6] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA 02115 USA

[7] Massachusetts Gen Hosp, Ctr Biostat, Boston, MA 02114 USA

[8] Harvard Univ, Sch Med, Boston, MA 02115 USA

[9] Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA

[10] Boston Univ, Sch Med, Dept Med, Genet Program, Boston, MA 02118 USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2008年 / 198卷 / 02期

关键词：

family study; fibroids; racial differences; symptom severity; uterine leiomyomata;

D O I：

10.1016/j.ajog.2007.05.038

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: The objective of the study was to identify risk factors for uterine leiomyomata (UL) in a racially diverse population of women with a family history of UL, and to evaluate their contribution to disease severity and age at diagnosis. STUDY DESIGN: We collected and analyzed epidemiologic data from 285 sister pairs diagnosed with UL. Risk factors for UL-related outcomes were compared among black (n = 73) and white (n = 212) sister pairs using univariate and multivariate regression models. RESULTS: Black women reported an average age at diagnosis of 5.3 years younger (SE, 1.1; P < .001) and were more likely to report severe disease (odds ratio, 5.22; 95% confidence interval, 1.99-13.7, P <.001) than white women of similar socioeconomic status. CONCLUSION: Self-reported race is a significant factor in the severity of UL among women with a family history of UL. Differences in disease presentation between races likely reflect underlying genetic heterogeneity. The affected sister-pair study design can address both epidemiological and genetic hypotheses about UL.

引用

页码：168.e1 / 168.e9

页数：9

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