Tricyclic antidepressants and non-Hodgkin lymphoma

被引:14
作者
Dalton, Susanne Oksbjerg [1 ]
Poulsen, Aslak Harbo [1 ]
Norgaard, Mette [2 ]
McLaughlin, Joseph K. [3 ,4 ]
Johansen, Christoffer [1 ]
Friis, Soren [1 ]
机构
[1] Danish Canc Soc, Inst Canc Epidemiol, DK-2100 Copenhagen, Denmark
[2] Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark
[3] Int Epidemiol Inst, Rockville, MD USA
[4] Vanderbilt Univ, Ctr Med, Vanderbilt Ingram Canc Ctr, Dept Med, Nashville, TN 37232 USA
关键词
D O I
10.1097/EDE.0b013e318176bf98
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: An increased risk of non-Hodgkin lymphoma (NHL) has been reported among long-term users of tricyclic antidepressants. Methods: The incidence of NHL among 43,932 users of any antidepressant medication (2 or more prescriptions) in the county of North Jutland, Denmark, during 1989-2003 was compared with NHL incidence in all those not using antidepressants (0 or 1 prescription). We used Poisson regression analysis adjusted for age, sex, period, use of immunosuppressive drugs, corticosteroids, or nonsteroidal anti-inflammatory drugs. Results: Use of tricyclic antidepressants was associated with an overall increased incidence of NHL (adjusted incidence rate ratio [IRR] = 1.53; 95% confidence interval [CI] 1.06-2.21) compared with nonuse. The IRR in users with >= 10 prescriptions and 5 or more years of follow-up was 2.50 (CI = 1.43-4.34). Users of other types of antidepressants were not at increased risk of NHL. Conclusions: Our results indicate an increased risk of non-Hodgkin lymphoma specifically among long-term users of tricyclic antidepressant medications.
引用
收藏
页码:546 / 549
页数:4
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