Metabolic regulation of organelle homeostasis in lupus T cells

被引：65

作者：

Caza, Tiffany N.

Talaber, Gergely

Perl, Andras ^{[1
]}

机构：

[1] SUNY Upstate Med Univ, Div Rheunnatol, Dept Med, Syracuse, NY 13210 USA

来源：

CLINICAL IMMUNOLOGY | 2012年 / 144卷 / 03期

关键词：

Systemic lupus erythematosus; T cell; Mitochondria; Endocytic recycling; Mammalian target of rapamycin; Autophagy; AUTOIMMUNE KIDNEY-DISEASE; RECEPTOR ZETA-CHAIN; RAPAMYCIN COMPLEX 1; SYSTEMIC-LUPUS; MAMMALIAN TARGET; MITOCHONDRIAL HYPERPOLARIZATION; MONOCLONAL-ANTIBODY; NITRIC-OXIDE; IMMUNOLOGICAL SYNAPSE; B-LYMPHOCYTE;

D O I：

10.1016/j.clim.2012.07.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Abnormal T-cell signaling and activation are characteristic features in systemic lupus erythematosus (SLE). Lupus T cells are shifted toward an over-activated state, important signaling pathways are rewired, and signaling molecules are replaced. Disturbances in metabolic and organelle homeostasis, importantly within the mitochondrial, endosomal, and autophagosomal compartments, underlie the changes in signal transduction. Mitochondrial hyperpolarization, enhanced endosomal recycling, and dysregulated autophagy are hallmarks of pathologic organelle homeostasis in SLE. This review is focused on the metabolic checkpoints of endosomal traffic that control immunological synapse formation and mitophagy and may thus serve as targets for treatment in SLE. (c) 2012 Elsevier Inc. All rights reserved.

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收藏

页码：200 / 213

页数：14

相关论文

共 176 条

[1]

Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis [J].

Alirezaei, Mehrdad ;

Fox, Howard S. ;

Flynn, Claudia T. ;

Moore, Craig S. ;

Hebb, Andrea L. O. ;

Frausto, Ricardo F. ;

Bhan, Virender ;

Kiosses, William B. ;

Whitton, J. Lindsay ;

Robertson, George S. ;

Crocker, Stephen J. .

AUTOPHAGY, 2009, 5 (02) :152-158

[2]

Interferon-γ selectively induces Rab5a synthesis and processing in mononuclear cells [J].

Alvarez-Dominguez, C ;

Stahl, PD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (51) :33901-33904

[3]

A Role for Autophagic Protein Beclin 1 Early in Lymphocyte Development [J].

Arsov, Ivica ;

Adebayo, Adeola ;

Kucerova-Levisohn, Martina ;

Haye, Joanna ;

MacNeil, Margaret ;

Papavasiliou, F. Nina ;

Yue, Zhenyu ;

Ortiz, Benjamin D. .

JOURNAL OF IMMUNOLOGY, 2011, 186 (04) :2201-2209

[4]

The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse [J].

Baixauli, Francesc ;

Martin-Cofreces, Noa B. ;

Morlino, Giulia ;

Carrasco, Yolanda R. ;

Calabia-Linares, Carmen ;

Veiga, Esteban ;

Serrador, Juan M. ;

Sanchez-Madrid, Francisco .

EMBO JOURNAL, 2011, 30 (07) :1238-1250

[5]

Interferon-γ is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice [J].

Balomenos, D ;

Rumold, R ;

Theofilopoulos, AN .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (02) :364-371

[6]

Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice [J].

Bao, LH ;

Haas, M ;

Kraus, DM ;

Hack, BK ;

Rakstang, JK ;

Holers, VM ;

Quigg, RJ .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 (03) :670-679

[7]

IL-15 and IL-15R in leucocytes from patients with systemic lupus erythematosus [J].

Baranda, L ;

de la Fuente, H ;

Layseca-Espinosa, E ;

Portales-Pérez, D ;

Niño-Moreno, P ;

Valencia-Pacheco, G ;

Abud-Mendoza, C ;

Alcocer-Varela, J ;

González-Amaro, R .

RHEUMATOLOGY, 2005, 44 (12) :1507-1513

[8]

PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus [J].

Barber, DF ;

Bartolomé, A ;

Hernandez, C ;

Flores, JM ;

Redondo, C ;

Fernandez-Arias, C ;

Camps, M ;

Ruckle, T ;

Schwarz, MK ;

Rodríguez, S ;

Martinez-A, C ;

Balomenos, D ;

Rommel, C ;

Carrera, AC .

NATURE MEDICINE, 2005, 11 (09) :933-935

[9]

Treatment of lupus-prone of TLR7 and TLR9 leads to mice with a dual inhibitor reduction of autoantibody production and amelioration of disease symptoms [J].

Barrat, Franck J. ;

Meeker, Thea ;

Chan, Jean H. ;

Guiducci, Cristiana ;

Cofftnan, Robert L. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2007, 37 (12) :3582-3586

[10]

Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells [J].

Battaglia, M ;

Stabilini, A ;

Roncarolo, MG .

BLOOD, 2005, 105 (12) :4743-4748

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