Mammary stem cells, self-renewal pathways, and carcinogenesis

被引：325

作者：

Liu, SL ^{[1
]}

Dontu, G ^{[1
]}

Wicha, MS ^{[1
]}

机构：

[1] Univ Michigan, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

BREAST CANCER RESEARCH | 2005年 / 7卷 / 03期

关键词：

D O I：

10.1186/bcr1021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The mammary gland epithelial components are thought to arise from stem cells that undergo both self-renewal and differentiation. Self-renewal has been shown to be regulated by the Hedgehog, Notch, and Wnt pathways and the transcription factor B lymphoma Mo-MLV insertion region 1 (Bmi-1). We review data about the existence of stem cells in the mammary gland and the pathways regulating the self-renewal of these cells. We present evidence that deregulation of the self-renewal in stem cells/progenitors might be a key event in mammary carcinogenesis. If 'tumor stem cells' are inherently resistant to current therapies, targeting stem cell self-renewal pathways might provide a novel approach for breast cancer treatment.

引用

页码：86 / 95

页数：10

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