Highly enantioselective hydrogenation of (E)-β-(acylamino)acrylates catalyzed by Rh(I)-complexes of electron-rich P-chirogenic diphosphines

被引：107

作者：

Yasutake, M ^{[1
]}

Gridnev, ID ^{[1
]}

Higashi, N ^{[1
]}

Imamoto, T ^{[1
]}

机构：

[1] Chiba Univ, Fac Sci, Dept Chem, Chiba 2638522, Japan

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 11期

关键词：

D O I：

10.1021/ol0158967

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Excellent enantioselectivities up to 99.7% were achieved in the hydrogenation of (E)-beta-(acylamino)acrylates by the use of Rh(I) complexes of electron rich diphosphines, t-Bu-BisP* and t-Bu-MiniPHOS. Low-temperature NMR experiments testify that monohydrides with P-carbon atom of the substrate bound to rhodium are involved in the catalytic cycle.

引用

页码：1701 / 1704

页数：4

共 33 条

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