Flurbiprofen Encapsulation Using Pluronic Triblock Copolymers

被引：57

作者：

Alexander, Shirin ^{[1
]}

Cosgrove, Terence ^{[1
]}

Prescott, Stuart W. ^{[1
]}

Castle, Thomas C. ^{[2
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] Revolymer Ltd, Mostyn CH8 9HE, Flint, Wales

来源：

LANGMUIR | 2011年 / 27卷 / 13期

基金：

英国工程与自然科学研究理事会;

关键词：

AQUEOUS-SOLUTIONS; BLOCK-COPOLYMERS; AIR/WATER INTERFACE; PHASE-BEHAVIOR; MICELLIZATION; NMR; SURFACTANTS; DIFFUSION; MICELLES; DELIVERY;

D O I：

10.1021/la201124c

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Pulsed-field gradient stimulated-echo nuclear magnetic resonance (NMR) and surface tension measurements have been used to study the effect of drug addition on the micellization behavior of pluronic triblock copolymers (P103, P123, and L43). The addition of 0.6 wt % flurbiprofen to Pluronic P123 and P103 solutions reduced their cmc and promoted micellization. Also, a substantial increase in the hydrodynamic radius of Pluronic P103 from 5 to 10 nm was observed, along with an increased fraction of polymer micellized, demonstrating that the polymers solubilize this nonsteroidal anti-inflammatory drug.

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收藏

页码：8054 / 8060

页数：7

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