Healthcare worker seroconversion in SARS outbreak

被引:20
作者
Chow, PKH
Ooi, EE
Tan, HK
Ong, KW
Sil, BK
Teo, M
Ng, T
Soo, KC
机构
[1] Singapore Gen Hosp, Dept Gen Surg, Singapore 169608, Singapore
[2] Genome Inst Singapore, Singapore, Singapore
关键词
D O I
10.3201/eid1002.030397
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 [免疫学];
摘要
Serum samples were obtained from healthcare workers 5 weeks after exposure to an outbreak of severe acute respiratory syndrome (SARS). A sensitive dot blot enzyme-linked immunosorbent assay, complemented by a specific neutralization test, shows that only persons in whom probable SARS was diagnosed had specific antibodies and suggests that subclinical SARS is not an important feature of the disease.
引用
收藏
页码:249 / 250
页数:2
相关论文
共 7 条
[1]
Identification of a novel coronavirus in patients with severe acute respiratory syndrome [J].
Drosten, C ;
Günther, S ;
Preiser, W ;
van der Werf, S ;
Brodt, HR ;
Becker, S ;
Rabenau, H ;
Panning, M ;
Kolesnikova, L ;
Fouchier, RAM ;
Berger, A ;
Burguière, AM ;
Cinatl, J ;
Eickmann, M ;
Escriou, N ;
Grywna, K ;
Kramme, S ;
Manuguerra, JC ;
Müller, S ;
Rickerts, V ;
Stürmer, M ;
Vieth, S ;
Klenk, HD ;
Osterhaus, ADME ;
Schmitz, H ;
Doerr, HW .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (20) :1967-1976
[2]
A novel coronavirus associated with severe acute respiratory syndrome [J].
Ksiazek, TG ;
Erdman, D ;
Goldsmith, CS ;
Zaki, SR ;
Peret, T ;
Emery, S ;
Tong, SX ;
Urbani, C ;
Comer, JA ;
Lim, W ;
Rollin, PE ;
Dowell, SF ;
Ling, AE ;
Humphrey, CD ;
Shieh, WJ ;
Guarner, J ;
Paddock, CD ;
Rota, P ;
Fields, B ;
DeRisi, J ;
Yang, JY ;
Cox, N ;
Hughes, JM ;
LeDuc, JW ;
Bellini, WJ ;
Anderson, LJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (20) :1953-1966
[3]
Severe acute respiratory syndrome - Providing care in the face of uncertainty [J].
Masur, H ;
Emanuel, E ;
Lane, HC .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (21) :2861-2863
[4]
Seroepidemiology of human enterovirus 71, Singapore [J].
Ooi, EE ;
Phoon, MC ;
Ishak, B ;
Chan, SH .
EMERGING INFECTIOUS DISEASES, 2002, 8 (09) :995-997
[5]
Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection [J].
Ruan, YJ ;
Wei, CL ;
Ee, LA ;
Vega, VB ;
Thoreau, H ;
Yun, STS ;
Chia, JM ;
Ng, P ;
Chiu, KP ;
Lim, L ;
Tao, Z ;
Peng, CK ;
Ean, LOL ;
Lee, NM ;
Sin, LY ;
Ng, LFP ;
Chee, RE ;
Stanton, LW ;
Long, PM ;
Liu, ET .
LANCET, 2003, 361 (9371) :1779-1785
[6]
Severe acute respiratory syndrome - Clinical outcome after inpatient outbreak of SARS in Singapore [J].
Tan, YM ;
Chow, PKH ;
Soo, KC .
BRITISH MEDICAL JOURNAL, 2003, 326 (7403) :1394-1394
[7]
*WHO, 2003, WKLY EPIDEMIOL REC, V8, P81