Histone acetylation and cancer

被引：237

作者：

Archer, SY ^{[1
]}

Hodin, RA ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Surg, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1999年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(99)80026-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the past year, several papers have been published which implicate a link between alterations in chromatin structure and the development of cancer. Both histone hyperacetylation and hypoacetylation appear to be important in the neoplastic process, depending on the target gene involved, In the case of colon cancer, induction of the p21 gene by histone hyperacetylation may be a mechanism by which dietary fiber prevents carcinogenesis.

引用

页码：171 / 174

页数：4

共 33 条

[1] Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
Alland, L
Muhle, R
Hou, H
Potes, J
Chin, L
SchreiberAgus, N
DePinho, RA
[J]. NATURE, 1997, 387 (6628) : 49 - 55
[2] ARCHER S, 1998, P NATL ACAD SCI USA, V95, P6971
[3] BARNARD JA, 1993, CELL GROWTH DIFFER, V4, P495
[4] BOFFA LC, 1992, CANCER RES, V52, P5906
[5] Retinoblastoma protein recruits histone deacetylase to repress transcription
Brehm, A
Miska, EA
McCance, DJ
Reid, JL
Bannister, AJ
Kouzarides, T
[J]. NATURE, 1998, 391 (6667) : 597 - 601
[6] BURKITT DP, 1971, CANCER, V28, P3, DOI 10.1002/1097-0142(197107)28:1<3::AID-CNCR2820280104>3.0.CO
[7] 2-N
[8] COLONIC FERMENTATION OF DIETARY FIBER TO SHORT CHAIN FATTY-ACIDS IN PATIENTS WITH ADENOMATOUS POLYPS AND COLONIC-CANCER
CLAUSEN, MR
BONNEN, H
MORTENSEN, PB
[J]. GUT, 1991, 32 (08) : 923 - 928
[9] A protein phosphatase is involved in the inhibition of histone deacetylation by sodium butyrate
Cuisset, L
Tichonicky, L
Delpech, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 246 (03) : 760 - 764
[10] Butyrate enemas in experimental colitis and protection against large bowel cancer in a rat model
DArgenio, G
Cosenza, V
DelleCave, M
Iovino, P
DellaValle, N
Lombardi, G
Mazzacca, G
[J]. GASTROENTEROLOGY, 1996, 110 (06) : 1727 - 1734

← 1 2 3 4 →