Neural correlates of traumatic memories in posttraumatic stress disorder: A functional MRI investigation

被引：347

作者：

Lanius, RA

Williamson, PC

Densmore, M

Boksman, K

Gupta, MA

Neufeld, RW

Gati, JS

Menon, RS

机构：

[1] Univ Western Ontario, London Hlth Sci Ctr, Dept Psychiat, London, ON N6A 5A5, Canada

[2] Univ Western Ontario, Dept Psychol, London, ON N6A 5A5, Canada

[3] Univ Western Ontario, Dept Med Biophys, London, ON N6A 5A5, Canada

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2001年 / 158卷 / 11期

关键词：

D O I：

10.1176/appi.ajp.158.11.1920

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: The neuronal circuitry underlying posttraumatic stress disorder (PTSD) was studied in traumatized subjects with and without PTSD. Method: Traumatized subjects with (N=9) and without (N=9) PTSD were studied by using the script-driven symptom provocation paradigm adapted to functional magnetic resonance imaging at a 4-T field strength. Results: PTSD subjects showed significantly less activation of the thalamus, the anterior cingulate gyrus (Brodmann's area 32), and the medial frontal gyrus (Brodmann's area 10/11) than did the comparison subjects. Conclusions: The findings suggest anterior cingulate, frontal, and thalamic involvement in the neuronal circuitry underlying PTSD.

引用

页码：1920 / 1922

页数：3

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