RNAi mechanisms in Caenorhabditis elegans

被引：121

作者：

Grishok, A ^{[1
]}

机构：

[1] MIT, Ctr Canc Res, Cambridge, MA 02139 USA

来源：

FEBS LETTERS | 2005年 / 579卷 / 26期

关键词：

RNAi; dsRNA; gene silencing; Caenorhabditis elegans;

D O I：

10.1016/j.febslet.2005.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA interference (RNAi) is a form of gene silencing induced by double stranded RNA (dsRNA) that is processed into short interfering RNAs (siRNAs). RNAi can induce both post-transcriptional and transcriptional gene silencing. In Caenorhahditis elegans, there are several distinct pathways where post-transcriptional or/and transcriptional RNAi mechanisms are involved. RNAi in C elegans is also systemic and heritable. This review will discuss RNAi related pathways, features of RNAi in C. elegans and possibilities of endogenous gene regulation by RNAi. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：5932 / 5939

页数：8

共 51 条

[1] microRNAs: Tiny regulators with great potential [J].