TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation

被引：294

作者：

Meyers, JH

Chakravarti, S

Schlesinger, D

Illes, Z

Waldner, H

Umetsu, SE

Kenny, J

Zheng, XX

Umetsu, DT

DeKruyff, RH

Strom, TB

Kuchroo, VK ^{[1
]}

机构：

[1] Brigham & Womens Hosp, Ctr Neurol Dis, Dept Neurol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Immunol, Boston, MA 02115 USA

[3] Stanford Univ, Sch Med, Dept Pediat, Div Immunol, Stanford, CA 94305 USA

来源：

NATURE IMMUNOLOGY | 2005年 / 6卷 / 05期

关键词：

D O I：

10.1038/ni1185

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The newly identified TIM family of proteins is associated with regulation of T helper type 1 (T(H)1) and T(H)2 immune responses. TIM-1 is genetically linked to asthma and is a receptor for hepatitis A virus, but the endogenous ligand of TIM-1 is not known. Here we show that TIM-4, which is expressed by antigen-presenting cells, is the ligand for TIM-1. In vivo administration of either soluble TIM-1-immunoglobulin (TIM-1-Ig) fusion protein or TIM-4-Ig fusion protein resulted in hyperproliferation of T cells, and TIM-4-Ig costimulated T cell proliferation mediated by CD3 and CD28 in vitro. These data suggest that the TIM-1-TIM-4 interaction is involved in regulating T cell proliferation.

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收藏

页码：455 / 464

页数：10

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