Combination antiretroviral therapy failure and HIV super-infection

被引：12

作者：

Bezemer, Daniela ^{[1
]}

van Sighem, Ard ^{[1
]}

de Wolf, Frank ^{[1
,2
]}

Cornelissen, Marion ^{[3
]}

van der Kuyl, Antoinette C. ^{[3
]}

Jurriaans, Suzanne ^{[3
]}

van der Hoek, Lia ^{[3
]}

Prins, Maria ^{[4
,5
]}

Coutinho, Roe A. ^{[5
,6
]}

Lukashov, Vladimir V. ^{[3
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, HIV Monitoring Fdn, NL-1105 AZ Amsterdam, Netherlands

[2] Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, London, England

[3] Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, Lab Expt Virol,CINIMA, NL-1105 AZ Amsterdam, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, NL-1105 AZ Amsterdam, Netherlands

[5] Hlth Serv Amsterdam, Dept Infect Dis, Amsterdam, Netherlands

[6] Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control, Bilthoven, Netherlands

来源：

AIDS | 2008年 / 22卷 / 02期

关键词：

D O I：

10.1097/QAD.0b013e3282f37489

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

In addition to development or selection of resistance, failure to continuously suppress HIV-1 production while still using initially effective combination antiretroviral therapy (cART) may result from super-infection with a drug-resistant strain. Both transmission of drug resistant HIV and super-infection have been demonstrated. We analysed HIV pol genes obtained before start of initially successful cART and during failure while still on cART in 101 patients. Difference in precART and cART failure sequences were explained by evolution and not by super-infection.

引用

页码：309 / 311

页数：3

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