DNA methylation changes in ovarian cancer: Implications for early diagnosis, prognosis and treatment

被引：147

作者：

Barton, Caroline A. ^{[1
]}

Hacker, Neville F. ^{[2
]}

Clark, Susan. J. ^{[1
]}

O'Brien, Philippa A. ^{[1
]}

机构：

[1] St Vincents Hosp, Garvan Inst Med Res, Canc Res Program, Darlinghurst, NSW 2010, Australia

[2] Royal Hosp Women, Gynaecol Canc Ctr, Sydney, NSW, Australia

来源：

GYNECOLOGIC ONCOLOGY | 2008年 / 109卷 / 01期

基金：

英国医学研究理事会;

关键词：

methylation; ovarian cancer; cancer biomarkers;

D O I：

10.1016/j.ygyno.2007.12.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective. To review epigenetic changes identified in ovarian cancer, focusing on their potential as clinical markers for detection, monitoring of disease progression and as markers of therapeutic response. Methods. A comprehensive review of English language scientific literature on the topics of methylation and ovarian cancer was conducted. Results. Genome-wide demethylation of normally methylated and silenced chromosomal regions, and hypermethylation and silencing of genes including tumor suppressors are common features of cancer cells. Epigenetic alterations, including CpG island DNA methylation, occur in ovarian cancer and the identification of specific genes that are altered by epigenetic events is an area of intense research. Aberrant DNA methylation in ovarian cancer is observed in early cancer development, can be detected in DNA circulating in the blood and hence provides the promise of a non-invasive cancer detection test. In addition, identification of ovarian cancer-specific epigenetic changes has promise in molecular classification and disease stratification. Conclusions. The detection of cancer-specific DNA methylation changes heralds an exciting new era in cancer diagnosis as well as evaluation of prognosis and therapeutic responsiveness and warrants further investigation. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：129 / 139

页数：11

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