Stem Cell Senescence and Regenerative Paradigms

被引：42

作者：

Beltrami, A. P. ^{[1
]}

Cesselli, D. ^{[1
]}

Beltrami, C. A. ^{[1
]}

机构：

[1] Univ Udine, Dept Med & Biol Sci, I-33100 Udine, Italy

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2012年 / 91卷 / 01期

关键词：

ENDOTHELIAL PROGENITOR CELLS; ACUTE MYOCARDIAL-INFARCTION; LIFE-SPAN; FUNCTIONAL CARDIOMYOCYTES; DIABETES-MELLITUS; HEART-FAILURE; MOUSE MODEL; IN-VITRO; MULTIPOTENT; GENERATION;

D O I：

10.1038/clpt.2011.262

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

The term "cellular senescence" denotes a cellular response to several stressors that results in irreversible growth arrest, alterations of the gene expression profile, epigenetic modifications, and an altered secretome, all of which eventually impair the reparative properties of primitive cells, adding a layer of complexity to the field of regenerative medicine. The purpose of this review is to illustrate how cellular senescence could affect tissue repair and to propose interventions that aim at interfering with it.

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页码：21 / 29

页数：9

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