Curculigo orchioides, a traditional Chinese medicinal plant, prevents bone loss in ovariectomized rats

被引：84

作者：

Cao, D. P. ^{[1
,2
]}

Zheng, Y. N. ^{[2
]}

Qin, L. P. ^{[1
]}

Han, T. ^{[1
]}

Zhang, H. ^{[1
]}

Rahman, Khalid ^{[3
]}

Zhang, Q. Y. ^{[1
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200433, Peoples R China

[2] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China

[3] Liverpool John Moores Univ, Fac Sci, Sch Biomol Sci, Liverpool L3 3AF, Merseyside, England

来源：

MATURITAS | 2008年 / 59卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Curculigo orchioides; ovariectomy; osteoporosis; serum biochemistry; bone mineral density;

D O I：

10.1016/j.maturitas.2008.03.010

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 [法学]; 0303 [社会学]; 100203 [老年医学];

摘要：

Objective: Natural medicines derived from plants have aroused increasing interest in the prevention and treatment of osteoporosis. This is due to their unique characteristics as these are more suitable for long-term use compared with synthesized chemicals and have apparently fewer adverse effects. Curculigo orchioides (CO) has a long history in the treatment of postmenopausal osteoporosis in traditional Chinese medicine. The present study was designed to investigate the protective effects of ethanol extracts of CO on ovariectomy-induced bone loss. Methods: Sixty female (4.5-month-old) Sprague-Dawley rats were assigned to sham and OVX groups. The OVX rats were further divided into five subgroups treated respectively, with vehicle, nylestriol (1 mg/kg, i.g.) and CO extract (0.5, 1.0, and 2.0 g/kg, i.g.) for 12 weeks. Bone mineral density (BMD) and bone mineral content (BMC) were measured by peripheral quantitative computerized tomography (pQCT) densitometry. Serum phosphorus, calcium, ACTH, corticosterone, deoxypyridinoline crossfinks to creatinine ratio (DPD/Cr), alkaline phosphate (ALP), tartrate-resistant acid phosphatase (TRAP), osteoprotegerin (OPG), IL-6, and TNF-alpha were also determined. Results: Administration of CO extract prevented bone loss in the trabecular bone of the tibia in ovariectornized rats without affecting the weight of the body and the uterus, and increased serum phosphorus, calcium, and OPG levels, decreased serum DPD/Cr, TRAP, ACTH, and corticosterone levels, but did not alter serum TNF-alpha, IL-6, and ALP levels in ovariectomized rats. Conclusion: CO ethanol extract has a definite protective effect on bone loss in ovariectomized rats by inhibiting bone resorption and increasing serum phosphorus and calcium levels, without affecting bone formation. Therefore, CO can be considered a potential anti osteoporosis herbal plant, although more studies are needed to clarify its real potential chemical constituents and their mechanism of action. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：373 / 380

页数：8

共 32 条

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Immunostimulatory effect of methanol extract of Curculigo orchioides on immunosuppressed mice [J].