COX-2 mRNA expression decreases in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low level laser therapy

被引:63
作者
Albertini, R. [1 ]
Aimbire, F. [1 ]
Villaverde, A. B. [1 ]
Silva, J. A., Jr. [1 ]
Costa, M. S. [1 ]
机构
[1] UNIVAP, IP&D, BR-12244 Sao Jose Dos Campos, Brazil
基金
巴西圣保罗研究基金会;
关键词
inflammation; COX-2; LLLT;
D O I
10.1007/s00011-007-6211-6
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Objective and design: Low level laser therapy (LLLT) has been presented as a novel therapy to treat inflammation. Herein we studied the effect of LLLT on the COX-2 mRNA expression in subplantar tissue taken from rats treated with carrageenan. Material: The groups consisted of 32 rats: A (1) (Saline), A (2) (Carrageenan), A (3) (Carrageenan + laser 660 nm) and A (4) (Carrageenan + laser 684 nm). Treatment: A(3) and A(4) were irradiated in the first hour after carrageenan. Methods: The edema was measured by a plethysmometer and COX-2 mRNA was by RT-PCR. Statistical were evaluated by ANOVA and Tukey-Kramer Test. Results: Carrageenan increased both edema (A(1)= 0.6 +/- 0.04 vs. A(2)= 2.24 +/- 0.08) and COX-2 mRNA (A(1)= 1.1 +/- 0.26 vs. A(2)= 3.52 +/- 0.69). Irradiation reduced the edema (A(3)= 0.84 +/- 0.09; A(4)= 1.31 +/- 0.05) and the COX-2 mRNA (A(3)= 2.16 +/- 0.28; A(4)= 1.86 +/- 0.20). Conclusion: LLLT reduce the expression of COX-2 mRNA.
引用
收藏
页码:228 / 229
页数:2
相关论文
共 7 条
  • [1] Effects of different protocol doses of low power gallium-aluminum-arsenate (Ga-Al-As) laser radiation (650 nm) on carrageenan induced rat paw ooedema
    Albertini, R
    Aimbire, FSC
    Correa, FI
    Ribeiro, W
    Cogo, JC
    Antunes, E
    Teixeira, SA
    De Nucci, G
    Castro-Faria-Neto, HC
    Zangaro, RA
    Lopes-Martins, RAB
    [J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2004, 74 (2-3) : 101 - 107
  • [2] The synthesis and distribution of the kinin B1 and B2 receptors are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy
    Argañaraz, GA
    Silva, JA
    Perosa, SR
    Pessoa, LG
    Carvalho, FF
    Bascands, JL
    Bader, M
    Trindade, ED
    Amado, D
    Cavalheiro, EA
    Pesquero, JB
    Naffah-Mazzacoratti, MD
    [J]. BRAIN RESEARCH, 2004, 1006 (01) : 114 - 125
  • [3] A randomised, placebo controlled trial of low level laser therapy for activated Achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations
    Bjordal, JM
    Lopes-Martins, RAB
    Iversen, VV
    [J]. BRITISH JOURNAL OF SPORTS MEDICINE, 2006, 40 (01) : 76 - 80
  • [4] DIFFERENTIATION-ASSOCIATED EXPRESSION OF PROSTAGLANDIN-G/H SYNTHASE IN MONOCYTIC CELLS
    HOFF, T
    DEWITT, D
    KAEVER, V
    RESCH, K
    GOPPELTSTRUEBE, M
    [J]. FEBS LETTERS, 1993, 320 (01) : 38 - 42
  • [5] Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation
    Nantel, F
    Denis, D
    Gordon, R
    Northey, A
    Cirino, M
    Metters, KM
    Chan, CC
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1999, 128 (04) : 853 - 859
  • [6] Tilley SL, 2001, J CLIN INVEST, V108, P15, DOI 10.1172/JCI13416
  • [7] Cyclooxygenases 1 and 2
    Vane, JR
    Bakhle, YS
    Botting, RM
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1998, 38 : 97 - 120