Reactivation and shedding of cytomegalovirus in astronauts during spaceflight

被引:147
作者
Mehta, SK
Stowe, RP
Feiveson, AH
Tyring, SK
Pierson, DL
机构
[1] NASA, Lyndon B Johnson Space Ctr, Life Sci Res Labs, Houston, TX 77058 USA
[2] Lyndon B Johnson Space Ctr, Enterprise Advisory Serv, Houston, TX 77058 USA
[3] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77550 USA
[4] Univ Texas, Med Branch, Dept Microbiol, Galveston, TX 77550 USA
关键词
D O I
10.1086/317624
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The reactivation of cytomegalovirus (CMV) in 71 astronauts was investigated, using polymerase chain reaction. A significantly greater (P < .0001) shedding frequency was found in urine samples from astronauts before spaceflight (10.6%) than in urine from the healthy control subject group (1.2%). Two of 4 astronauts studied during spaceflight shed CMV in urine. A significant increase (P < .0001) in CMV antibody titer, compared with baseline values, was also found 10 days before spaceflight. CMV antibody titer was further increased (P < .001) 3 days after landing, compared with 10 days before the mission. Significant increases in stress hormones were also found after landing, These results demonstrate that CMV reactivation occurred in astronauts before spaceflight and indicate that CMV may further reactivate during spaceflight.
引用
收藏
页码:1761 / 1764
页数:4
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